Amanda Lautieri is a Senior Content Editor at American Addiction Centers. She has more than 10 years of professional editing experience that includes working as a web editor for several major online publishers and editing medical content ranging from academic texts to online training and re-certification courses for emergency medical service responders. Opiate drugs, including prescription painkillers and heroin, can produce withdrawal symptoms just hours after the last dose, and the symptoms can last for a week or more. Unassisted withdrawal may not be life-threatening, but it can lead to relapse. Medications and therapy, accessed in medical detox, may make relapse less likely. Withdrawal symptoms include: The National Institute on Drug Abuse (NIDA) publishes that between 26.4 million and 36 million people around the globe abuse opiate drugs, which includes prescription pain relievers and the illegal drug heroin. 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