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Fluconazole chemical structure

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  1. jazzyfanka Well-Known Member

    Fluconazole chemical structure


    Antifungal, in the same drug family as ketoconazole and itraconazole. Fluconazole has many advantages over the other antifungal drugs including the option of oral administration. does cipro cause constipation Fluconazole is a first-generation triazole antifungal medication. It differs from earlier azole antifungals (such as ketoconazole) in that its structure contains a triazole ring instead of an imidazole ring. While the imidazole antifungals are mainly used topically, fluconazole and certain other triazole antifungals are preferred when systemic treatment is required because of their improved safety and predictable absorption when administered orally. Fluconazole's spectrum of activity includes most Candida species (but not Candida krusei or Candida glabrata), Cryptococcus neoformans, some dimorphic fungi, and dermatophytes, among others. Common uses include: Fungal resistance to drugs in the azole class tends to occur gradually over the course of prolonged drug therapy, resulting in clinical failure in immunocompromised patients (e.g., patients with advanced HIV receiving treatment for thrush or esophageal Candida infection). albicans, resistance occurs by way of mutations in the ERG11 gene, which codes for 14α-demethylase. These mutations prevent the azole drug from binding, while still allowing binding of the enzyme's natural substrate, lanosterol. glabrata is increasing the rate of efflux of the azole drug from the cell, by both ATP-binding cassette and major facilitator superfamily transporters. Development of resistance to one azole in this way will confer resistance to all drugs in the class. Other gene mutations are also known to contribute to development of resistance.

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    Structure, properties, spectra, suppliers and links for Fluconazole, Diflucan. Molecular FormulaC13H12F2N6O; Average mass306.271 Da; Monoisotopic. purchase tretinoin .1 P. Dorr, in Comprehensive Medicinal Chemistry II, 2007. however, it should not have the 13-dioxolane ring system present in the structures of 23, 24, and 25. Melting point °C, 138-140 °C, water solubility, slightly soluble in water.

    Fluconazole is only found in individuals that have used or taken this drug. It is a triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS. Fluconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Fluconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis. Fluconazole is a novel kind triazole drug of anti-fungal infection which was first successfully developed by the American Pfizer with broad-spectrum anti-fungal effect. It belongs to a kind of systemic anti-fungal products and has high selectivity on the inhibitory effect of the fungal cytochrome P450-dependent enzyme. It is also a kind of potent and specific inhibitor for the fungi alcohol synthesis. Clinically it is mainly used for the treatment of vaginal candidiasis, thrush, atrophic oral candidiasis, fungal meningitis, pulmonary fungal infections, abdominal infections, urinary tract infections and skin fungi infection. The main indication for fluconazole as follows: 1, systemic candidiasis: including candidemia, disseminated candidiasis and other forms of invasive Candida infections such as the peritoneum, endocardium, lungs and urinary tract infections. It can also be applied to patients of malignant tumors, special-care patients, patients who received radiotherapy, chemotherapy or immunosuppressive therapy as well as patients who are susceptible to other factors such as infection of Candida. It can also be used for prevention of the occurrence of candida infection for bone marrow transplant patients upon receiving cytotoxic drugs treatment or radiation treatment.

    Fluconazole chemical structure

    RFHAOTPXVQNOHP-CQOLUAMGSA-N C13H12F2N6O - PubChem, Fluconazole - Science Direct

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  3. Visit ChemicalBook To find more Fluconazole86386-73-4 information like chemical properties,Structure,melting point,boiling point,density,molecular formula.

    • Fluconazole 86386-73-4 - ChemicalBook
    • DB00196 Fluconazole - Fluconazole - DrugBank
    • RCSB PDB - TPF Ligand Summary Page

    Melting point °C, 138-140 °C, 3248 water solubility, slightly soluble in water. clonidine effects DRUG Fluconazole, Help. Entry. D00322 Drug. Name. Fluconazole JP17/USAN /INN; Fluconazole capsules JP17;. Chemical structure group DG00371. Fluconazole ≥98% HPLC, powder; CAS Number 86386-73-4; Synonym 2-2,4-Difluorophenyl-1. Linear Formula C13H12F2N6O; find Sigma-Aldrich-F8929 MSDS, related peer-reviewed papers. plasmid vector for molecular cloning.

     
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