An important link between alcohol and breast cancer has been discovered by identifying a cancer-causing gene triggered by alcohol, scientists report. It is estimated that tens of thousands of breast cancer cases in the U. and Europe each year are attributable to alcohol consumption and that drinking is also associated with an increased risk of disease recurrence in women with early stage breast cancer. "Alcohol consumption is prevalent among women in the U. and is a risk factor for breast cancer," said UH cancer biologist Chin-Yo Lin. "Our research shows alcohol enhances the actions of estrogen in driving the growth of breast cancer cells and diminishes the effects of the cancer drug Tamoxifen on blocking estrogen by increasing the levels of a cancer-causing gene called BRAF." Chin-Yo Lin, University of Houston Lin, an assistant professor with the UH Center for Nuclear Receptors and Cell Signaling and the Department of Biology and Biochemistry, and his former Ph. student, Nicholes Candelaria, describe their findings in a paper titled "Alcohol Regulates Genes that Are Associated with Response to Endocrine Therapy and Attenuates the Actions of Tamoxifen in Breast Cancer Cells," recently appearing in , an open access peer-reviewed scientific journal published by the Public Library of Science. Lin and Candelaria, who graduated from UH in 2015 and is currently a post-doctoral fellow at Baylor College of Medicine, collaborated with alcohol researcher Rajesh Miranda, a professor at Texas A&M University. It is estimated that tens of thousands of breast cancer cases in the U. and Europe each year are attributable to alcohol consumption and that drinking is also associated with an increased risk of disease recurrence in women with early stage breast cancer. The study objective was to determine how alcohol can affect the actions of estrogen in breast cancer cells. Tamoxifen is a hormonal therapy drug used to treat breast cancer, womb cancer and sometimes other cancers and conditions. It is best to read this information with our general information about hormonal therapies and the type of cancer you have. Like all cancer drugs, tamoxifen can cause side effects. Your cancer doctor, nurse, or pharmacist will tell you how often you will have it. Some of the side effects can be serious, so it is important to read the detailed information below. Your healthcare team can give you advice on how to manage any side effects. Tell your doctor or nurse straight away if you feel unwell or have severe side effects, including any we do not mention here. Your cancer doctor or nurse can explain the risk of these side effects to you. If you need medical attention for any reason other than cancer, always tell the healthcare staff that you are having this treatment. Tamoxifen can be given alone or with other types of treatment. Amoxicillin for cold Diflucan class Generic for zoloft Mar 2, 2006. Are there any specific negative effects of drinking alcohol while taking tamoxifen after chemotherapy and radiation therapy? Is it OK to have. Yes it is fine to have alcohol while on tamoxifen and also while having chemo. My doc said try to keep your life as normal as possible, if you want to have a drink, have it. Sit back, have a drink and relax. Good luck. Conclusion Tamoxifen may modify the association between alcohol intake and serum hormones and peptides. The significant associations found for DHEAS and SHBG are in a direction considered unfavorable for breast cancer prognosis. Dear Onco Link "Ask The Experts,"Are there any specific negative effects of drinking alcohol while taking tamoxifen after chemotherapy and radiation therapy? Nancy Zieber, RN, MSN, CRNP, Oncology/Hematology Nurse Practitioner, responds: The only problem or potential issue I see with drinking alcohol while taking Tamoxifen is that both can affect the liver and raise liver enzymes. If the liver is healthy and there are no previous liver problems, then drinking alcohol is OK. While not all chemotherapy drugs affect the liver, many can, and so it is best to err on the side of caution. I would state that excessive alcohol (more than 7 drinks per week for women, or greater than 3 drinks at any one time) may negatively alter the immune system. We do know that women with breast cancer who are alcoholics have a less favorable outcome (meaning higher rates of recurrence and death). Occasional alcohol intake should not cause any problematic interaction with radiation therapy to the breast. The interaction between Tamoxifen and alcohol is considered moderate, but studies have shown that consuming alcohol while taking this medication can decrease the drug’s effectiveness and increase the likelihood of more serious side effects. Tamoxifen (Nolvadex, Soltamox) is a drug that is used to block the production of certain hormones in the body that may be partially responsible for promoting the growth of breast cancer. It is often given to men who have breast cancer or to women who either have the disease or who have certain genetic markers indicating that they could develop the disease in the future. As a result, people of either sex are at risk for interactions between Tamoxifen and alcohol and should understand the possible side effects that they could experience as well as how much alcohol is considered safe while being treated with the medication. Some of the potential side effects that may occur when using Tamoxifen and drinking alcohol together include dizziness, drowsiness and even increased risks for heart attacks and strokes. One of the most prominent side effects of Tamoxifen is dizziness, and alcohol can certainly increase this—even when consumed in very small amounts. Also, alcohol has been shown to increase the risk of breast cancer, which is exactly what Tamoxifen was developed to fight. Tamoxifen alcohol Drinking after breast cancer won't raise mortality risk, study shows, Is it ok to have alcohol while on Tamoxifen? Beyond The Shock® Where to buy cytotec in dumagueteZithromax medicationClonidine dose adhdCanadian medsValacyclovir hcl Tamoxifen is a pill taken every day for 5-10 years. For premenopausal women, tamoxifen may be combined with ovarian suppression. The benefits from tamoxifen last long after you stop taking it. Tamoxifen for Breast Cancer Treatment - Susan G. Komen. Breast Cancer Topic drinking alcohol. Tamoxifen ≥99% Sigma-Aldrich. Alcohol drinking is one of the most well-established risk factors for breast cancer. Alcohol consumption increases the risk of breast cancer for younger women. Mar 16, 2016. Another key finding was that alcohol weakened Tamoxifen's ability to suppress the rapid growth of cancer cells. Lin and his colleagues posit. Tamoxifen is approved for this use regardless of menopausal status. Raloxifene is approved for use only in postmenopausal women. Two aromatase inhibitors — exemestane and anastrazole —have also been found to reduce the risk of breast cancer in postmenopausal women at increased risk of the disease.