Why chloroquine start with loading dose

Discussion in 'Plaquenil' started by anonim, 04-Mar-2020.

  1. rtfm Well-Known Member

    Why chloroquine start with loading dose


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. -Each dose should be taken with a meal or a glass of milk.

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    The standard chloroquine dose for treating malaria in adults is a one-time loading dose of 1000 mg, followed by 500 mg in six to eight hours. Then 500 mg is taken once a day for two more days. The standard dosage for malaria treatment in children is based on the child's weight. Oct 01, 2018 Each 500 mg tablet of Chloroquine phosphate contains the equivalent of 300 mg Chloroquine base. In infants and children the dosage is preferably calculated by body weight. Adult Dose The dosage for prophylaxis is 500 mg = 300 mg base administered once per week on exactly the same day of each week. Chloroquine-resistant malaria or sensitivity not known. Quinine adults 20 mg dihydrochloride salt/kg of body weight loading dose 1 diluted in 10 ml isotonic fluid/kg by IV infusion over 4 hours; then 8 hours after the start of the loading dose, give a maintenance dose of quinine, 10 mg salt/kg, over 4 hours.

    -Concomitant therapy with an 8-aminoquinoline drug is necessary for the radical cure of vivax and malariae malaria. Use: Malaria prophylaxis Acute attack: 800 mg (620 mg base) orally followed in 6 to 8 hours by 400 mg (310 mg base), then 400 mg (310 mg base) once a day for 2 consecutive days; alternatively, a single dose of 800 mg (620 mg base) has also been effective Alternate dosing based on body weight: A total dose representing 25 mg/kg is administered in 3 days, as follows: First dose: 10 mg base/kg (not to exceed 620 mg base) orally Second dose: 5 mg base/kg (not to exceed 310 mg base) orally 6 hours after first dose Third dose: 5 mg base/kg orally 18 hours after second dose Fourth dose: 5 mg base/kg orally 24 hours after third dose Comments: -Each dose should be taken with a meal or a glass of milk.

    Why chloroquine start with loading dose

    Chloroquine Prevention of Coronavirus Disease COVID-19 in the., Chloroquine - FDA prescribing information, side effects and uses

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  4. Drugs which may be started with an initial loading dose include digoxin, teicoplanin, voriconazole, procainamide and fulvestrant. One or series of doses that may be given at the onset of therapy with the aim of achieving the target concentration rapidly.

    • Loading dose - Wikipedia.
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    A number of studies demonstrate that creatine is safe over both short- and long-term periods 1, 2, 9, 10. According to the International Society of Sports Nutrition ISSN, up to 30 grams per day. Loading dose is calculated by multiplying the desired peak concentration by the volume of distribution of the drug. If the dosing interval is the same as the half-life of the drug, the loading dose should be twice the maintenance dose i.e. after one half-life the drug concentration will have dropped by half. The excretion of chloroquine and the major metabolite, desethylchloroquine, in breast milk was investigated in 11 lactating mothers following a single oral dose of chloroquine 600 mg basemaximum daily dose of the drug that the infant received from breast-feeding was about 0.7% of the maternal start dose of the drug in malaria chemotherapy.

     
  5. Jeff Swan Moderator

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Plaquenil and Sun Sensitivity - Reviews Hydroxychloroquine Uses, Dosage & Side Effects - Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses
     
  6. FastVPS.ru User

    New Plaquenil Guidelines Problems with Plaquenil Use Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders.

    Hydroxychloroquine Plaquenil Toxicity and Recommendations.