Chloroquine phosphate pharmacokinetics

Discussion in 'Plaquenil' started by AlexVan, 02-Mar-2020.

  1. Podor Well-Known Member

    Chloroquine phosphate pharmacokinetics


    It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc.

    Hydroxychloroquin safety Plaquenil eye grib waves

    Chloroquine CQ is an important antimalarial drug for the treatment of special patient groups and as a comparator for preclinical testing of new drugs. Pharmacokinetic data for CQ in animal models are limited; thus, we conducted a three-part investigation. Chloroquine Phosphate is the phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Hydroxychloroquine HCQ and chloroquine CQ are well absorbed 0.7-0.8 bioavailability when given orally. Severe malnutrition such as kwashiorkor effects absorption but diahrrea does not. Both HCQ and CQ have prolonged half-lives, between 40 and 50 days, and low blood clearance e.g. hydroxychloroquine's blood clearance is 96 ml/min.

    The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea.

    Chloroquine phosphate pharmacokinetics

    Clinical Pharmacokinetics and Metabolism of Chloroquine., Chloroquine phosphate C18H32ClN3O8P2 - PubChem

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  4. Mg 250 mg of chloroquine phosphate daily. a When used in conjunction with topical corticosteroids in treatment of discoid lupus erythematosus, skin lesions may regress within 3–4 weeks and new lesions may not appear. a When systemic and cutaneous manifestations of lupus erythematosus subside.

    • Chloroquine Phosphate Monograph for Professionals -.
    • Pharmacokinetics of hydroxychloroquine and chloroquine..
    • Chloroquine - Wikipedia.

    Total maximum dose is 2.5 g chloroquine phosphate 1.5 g base in 3 days. The CDC recommends adding primaquine for P. vivax or P. ovale. The CDC recommends chloroquine as an option in uncomplicated malaria in patients with chloroquine-sensitive P. falciparum or P. vivax or in all patients with P. malariae, P. Chloroquine Phosphate. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. Pharmacokinetics Hydroxychloroquine has similar pharmacokinetics to chloroquine, with rapid gastrointestinal absorption and elimination by the kidneys. Cytochrome P450 enzymes CYP2D6, 2C8, 3A4 and 3A5 metabolize hydroxychloroquine to N -desethylhydroxychloroquine.

     
  5. WaterSpirit Well-Known Member

    Hydroxychloroquine is in a class of drugs called antimalarials. Lupus Light Sensitivity and Other Eye Symptoms - TheraSpecs Plaquenil Hydroxychloroquine - Side Effects, Dosage. Hydroxychloroquine Indications, Side Effects, Warnings -
     
  6. MakStudio Guest

    Sulfasalazine Compared to Alternatives - Had to stop taking Humira and methotrexate due to repeated bouts with pneumonia and lung damage. Currently on sulfasalazine, Plaquenil and prednisone. Occasional flares but things are basically back under control.

    Plaquenil hydroxychloroquine sulfate dose, indications, adverse.