This medicine is also sometimes given off-label to help the following conditions: Also, let your doctor know if you drink large amounts of alcohol before starting on this medicine. Your doctor will probably want to order frequent tests to check your body's response to chloroquine. Chloroquine inhibits autophagic flux by decreasing autophagosome lysosome fusion Chloroquine rheumatoid arthritis mechanism of action Benefits drawbacks hydroxychloroquine Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. It is also occasionally used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. If you are also taking kaolin or antacids, take them at least 4 hours before or after using chloroquine. If you are also taking ampicillin, take it at least 2 hours before or after using this medicine. Dosing. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. What Is the Chloroquine Dosage for Preventing Malaria? The usual dosage for malaria prevention in adults is 500 mg once a week. The chloroquine dose in children is based on the child's weight. Children either receive about 8.3 mg per kg of body weight about 3.8 mg per pound of body weight or the adult dose, whichever is less. Let your healthcare provider know if your symptoms either don't improve or worsen while taking this medicine. Keep all appointments with your doctor and laboratory. Chloroquine dose in pediatrics Chloroquine Aralen - Side Effects, Dosage, Interactions., Chloroquine Oral Route Proper Use - Mayo Clinic Pregnancy category hydroxychloroquineDoes hydroxychloroquine cause bone grafts to failHow to stop itching from chloroquine injection Comparative study of chloroquine and quinine on malaria rodents and their effects on the mouse testis. Chloroquine was administered to the mice in the first group as 20 mg/kg b.w. once a day for four consecutive days. Quinine at a dose of 20 mg/kg b.w. was given to the mice in the second group for the first day and 10 mg/kg b.w. for the. Comparative study of chloroquine and quinine on malaria.. Chloroquine Dosage - Malaria Home Page. Chloroquine Use During Pregnancy. The American Academy of Pediatrics “ AAP ” hosts the Website and related Materials on its servers and makes them available via the Internet to subscribers for non-commercial research and education purposes and for use in providing healthcare services. In consideration of payment of the applicable subscription fee, the AAP is willing to. The excretion of chloroquine and the major metabolite, desethylchloroquine, in breast milk was investigated in 11 lactating mothers following a single oral dose of chloroquine 600 mg basemaximum daily dose of the drug that the infant received from breast-feeding was about 0.7% of the maternal start dose of the drug in malaria chemotherapy. Usual Adult Dose for Malaria Prophylaxis. Suppression 400 mg 310 mg base orally on the same day every week Comments-Suppressive therapy should begin 2 weeks prior to exposure; however, failing this, an initial dose of 800 mg 620 mg base may be taken in 2 divided doses 6 hours apart.