Although their therapeutic and toxic doses differ, they are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity. The image below depicts hydroxychloroquine retinopathy. Fluorescein angiogram of left macula in patient with hydroxychloroquine retinopathy. Chloroquine malaria dna binding theory Hydroxychloroquine and reduction of metastasis Hydroxychloroquine ms Aug 29, 2014 Plaquenil, hydroxychloroquine HCQ, is an anti-malarial medication that has been proven to be useful in the treatment of patients with rheumatoid arthritis RA, systemic lupus erythematosus SLE and other inflammatory and autoimmune diseases. Plaquenil, widely used to treat lupus, rheumatoid arthritis and other inflammatory and dermatologic conditions, is very effective, and “the risk of toxicity in the first five years for someone without special risk factors is very low,” Dr. Marmor said. However, risk increases with duration of use. Additionally, color vision––helping in the assessment of macular integrity––was recommended as an optional test. There have been reports of color vision defects associated with chloroquinine- and hydroxychloroquinine-related retinal toxicity. 4 Other optional tests included multifocal electrophysiology mfERG testing and fluorescein. Retinopathy may be asymptomatic or may cause central or paracentral scotomas leading to difficulty reading or performing fine visual tasks (due to parafoveal metamorphopsia). Reprinted from American Journal of Ophthalmology, Vol 104, Johnson and Vine, Hydroxychloroquine therapy in massive total doses without retinal toxicity, pages 139-144, Copyright 1987, with permission from Elsevier Science. Color dx test results in plaquenil toxicity ColorDx CCT HD color vision diagnostics Konan Medical, Rx Side Effects New Plaquenil Guidelines and More - American. Eye report for hydroxychloroquine Here are 10 things to keep in mind when using Plaquenil Take it on a regular schedule, meaning at the same time each day. Take Plaquenil EXACTLY as prescribed by your physician. Do not stop taking the medication without first speaking to your doctor. Taking Hydroxychloroquine with food and/or milk can help prevent stomach upset. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. New Plaquenil Guidelines. Has anyone experienced plaquenil toxicity with damage to eyes?. Physician’s order e.g. Extended color vision testing to rule out Plaquenil macula toxicity – patient unable to complete 10-2 HVF Reliability of the test e.g. Prompt responses Findings e.g. Some red-green defects noted OU Assessment, diagnosis e.g. Plaquenil macula toxicity OU; no prior hx of color vision defects This article is from June 2011 and may contain outdated material. Download PDF. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. Lyons emphasizes the importance of annual screening and says that, although annual screening is recommended for everyone taking Plaquenil, it is imperative for people who have been taking the medication for more than 10 years, who have a higher incidence of retinal toxicity. Plaquenil-induced toxicity usually will not occur before five years of.