Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Plaquenil toxicity retina Plaquenil and adrenal insufficiency Hydroxychloroquine 50 mg Plaquenil or hydroxychloroquine is under the quinolone family. These medications are initially used in the prophylaxis and treatment of malaria. Plaquenil has replaced chloroquine because it produces less retinal side effects. Hydroxychloroquine Retinopathy with SD-OCT Changes and Minimal Fundus Changes. The images shown here refer to the same case as "Hydroxychloroquine Retinopathy with Minimal Fundus Changes". This 68 year old woman with systemic lupus erythematosus had been on hydroxychloroquine at a dosage of 400 mg/d 6.52 mg/kg/d for eight years. May 16, 2011 Hydroxychloroquine Plaquenil; HCQ has been an important and effective drug for the treatment of lupus erythematosus and related autoimmune and inflammatory diseases for half a century, although its potential to cause retinal damage continues to raise concern among rheumatologists and ophthalmologists. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Plaquenil retnopathy oct Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy, Hydroxychloroquine Retinopathy with SD-OCT Changes and. Plaquenil immune systemChloroquine medscape Aug 06, 2014 Figure 2. Spectral-domain optical coherence tomography demonstrating advanced hydroxychloroquine retinopathy with parafoveal loss of the external limiting membrane, disruption of the outer ellipsoid zone, thinning of the outer nuclear layer and disruption to the underlying retinal pigment epithelial layer A. Multimodal Imaging in Plaquenil Toxicity. Hydroxychloroquine Retinopathy Still Alive and Well - The.. Expanded spectral domain-OCT findings in the early.. Background/Aims Hydroxychloroquine HCQ retinopathy may result in severe and irreversible vision loss, emphasising the importance of screening and early detection. The purpose of this study is to report the novel finding of early optical coherence tomography OCT abnormalities due to HCQ toxicity that may develop in the setting of normal Humphrey visual field HVF testing. Methods Data from. Dence of hydroxychloroquine maculopathy. Table. Clinical, High-Speed Ultra–High-Resolution Optical Coherence Tomography, and Multifocal Electroretinogram Findings From Patients Receiving Hydroxychloroquine Patient No./ Age, y Hydroxychloroquine Dosage, mg/d Diagnosis Treatment, y Symptoms Visual Acuity, OD, OS Color Vision Visual Fields mfERG. Apr 20, 2011 8. Kellner S, Weinitz S, Kellner U. Spectral domain optical coherence tomography detects early stages of chloroquine retinopathy similar to multifocal electroretinography, fundus autofluorescence and near-infrared autofluorescence. Br J Ophthalmol. 2009 Nov;93111444-7. 9. Lai TY, Ngai JW, Chan WM, Lam DS.