Derm Net NZ Medical Editor: Dr Delwyn Dyall-Smith, Dermatologist, Wagga Wagga, NSW, Australia. However, following an identical dose of hydroxychloroquine and chloroquine, tissue levels of chloroquine are 2.5 times those of hydroxychloroquine. Derm Net NZ Editor in Chief: Adjunct Prof Amanda Oakley, Dermatologist, Hamilton, New Zealand. Hydroxychloroquine is preferred due to its safer profile. Chloroquine for infants Hydroxychloroquine cause peptic ulcer Plaquenil 200 mg efectos secundarios How does plaquenil fight malaria Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Use of antimalarials ie, quinacrine, chloroquine, hydroxychloroquine HCQ can induce tissue pigmentation in a variety of organs, including skin, joint tissue, trachea, and cartilage in the nose and ears. Chloroquine phosphate tablets, Chloroquine phosphate, USP, is a 4-aminoquinoline compound for oral administration. It is a white, odorless, bitter tasting, crystalline substance, freely soluble inwater. Chloroquine phosphate tablets are an antimalarial and amebicidal drug. Hydroxychloroquine is considered safer than chloroquine during pregnancy and lactation. If there is a of hydroxychloroquine, although studies have not usually confirmed this clinical impression. Chloroquine pigmentation Antimalarial Induced Skin Pigmentation, Hydroxychloroquine-Induced Pigmentation in Patients With. Plaquenil retinopathy guidelinesIs plaquenil harmfulHydroxychloroquine for lichen planus Multiple pathologic mechanisms are responsible for drug-induced pigmentation disorders. Compared with the immunological etiology underlying many drug allergies, most cases of pharmacologic pigmentation are not immunologically mediated. Drug-Induced Pigmentation Background, Pathophysiology.. Chloroquine - FDA prescribing information, side effects.. Chloroquine - FDA prescribing information, side effects and uses. Pigmentation has been associated with drug therapy or adrenal insufficiency; however, in many cases the cause cannot be identified 15. The greatest significance of chloroquine-induced hyper-pigmentation is the possibility that it may be a marker for a more serious side effect. Irreversible retinopathy Mucocutaneous hyperpigmentation because of anti-malarial therapy has been reported since World War II 2; however, HCQ-associated hyperpigmentation seems to be less common than with other antimalarials such as chloroquine 3,4onset of HCQ-associated hyperpigmentation ranges from 3 months to 22 years following the initiation of therapy, with a median of 6.1 years 1. The anti-malarial agent chloroquine diphosphate, which is also used to treat immunological, dermatological, and rheumatological disorders, usually causes pigmentary changes in the oral mucosa. This report presents a case of palate pigmentation related to the prolonged use of chloroquine diphosphate caused by the deposition of drug metabolites in the mucosa.