Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Medicare allowable testing for chloroquine therapy Chloroquine avloclor Toxicity of chloroquine Psoriasis from generic plaquenil A daily dose of chloroquine 3 mg/kg and a treatment duration of 5 years are considered important risk factors for the development of retinopathy. Therefore, patients who are taking chloroquine or hydroxychloroquine should have regular ophthalmic examinations to detect retinal changes as early as possible in order to minimize retinal toxicity. Sorsby Syndrome. Bull’s eye maculopathy is a rare dystrophy, also known as benign concentric annular macular dystrophy BCAMD. ABCA4 retinopathy may present with a wide spectrum of phenotypic variability, from AMD 2 in heterozygous carriers to bull’s- eye maculopathy, 3,4 AR-cone-rod dystrophy. Hydroxychloroquine or chloroquine ingestion can cause atrophy of the retinal pigment epithelium in the form of a bull’s eye maculopathy in cases of chronic use. Early detection of toxicity prior to the development of the bull’s eye is important, as loss of visual acuity is usually irreversible at that stage. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Bulleye chloroquin retinopathy Chloroquine-induced bull’s eye maculopathy, Bull's Eye Maculopathy Causes & Reasons - Symptoma Does plaquenil help fight infectionsCan plaquenil help fatiguePlaquenil pictures Aug 30, 2011 Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1. It is now considered for new disease applications in diabetes, heart disease and adjunct cancer therapies 2. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. Macular Telangiectasia A cause of bull’s eye maculopathy. Bull's-eye Maculopathy Associated With Chronic Macular Hole JAMA.. Hydroxychloroquine Maculopathy An Update on Screening and Diagnosis A brief guide for imaging SHIRI SHULMAN, MD. H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. Causes of Bull's Eye maculopathy include cone dystrophy cone-rod dystrophy chloroquine or hydroxychloroquine toxicity ceroid lipofuscinosis Stargardt's and fundus flavimaculatus fenestrated sheen macular dystrophy parafoveal atrophy of RPE secondary to AMD central areolar choroidal dystrophy benign concentric annular macular dystrophy Juvenile Batten's disease fucosidosis clofazimine maculopathy Bull’s eye maculopathy is a rare dystrophy, also known as benign concentric annular macular dystrophy BCAMD. It causes a dartboard, or ring-shaped, pattern of damage around the macula. This characteristic damage can also be caused by other inherited retinal conditions, or by long-term use of drugs which suppress.