Collagen, a key component important of scar tissue, can in excess lead to hardened and thickened tissue in organs and joints. There is no cure for scleroderma, but available treatments can help to manage its symptoms and reduce its severity. Chloroquine sulphate Hydroxychloroquine yellow Aralen cloroquina Anti-malarial drugs, such as Plaquenil hydroxychloroquine, is often used to manage lupus and can also be effective in scleroderma. Plaquenil is thought to interfere with communication between immune cells, which can suppress the damaging effect of an overly active immune response without raising a patient’s risk of susceptibility to infections. Systemic sclerosis scleroderma is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 10+ years, also take medication Lasix, and have Osteoporosis Currently, there is no cure for scleroderma. Instead, treatment is directed at controlling and managing the symptoms. Because scleroderma can have many symptoms, a combination of approaches is often needed to treat and manage the disease effectively. Skin treatments For localized scleroderma, topical medications often are beneficial. Moisturizers are used to prevent the skin from drying out, as well as to treat hardened skin. These have been helpful in managing the symptoms of both systemic and localized scleroderma. For some scleroderma patients, medications used to treat malaria may be prescribed. Plaquenil localized scleroderma What is the course of progression for scleroderma? Skin., Plaquenil and Systemic sclerosis scleroderma - from FDA. Plaquenil preretinopathyPlaquenil and lymphadenopathy What is scleroderma? Scleroderma is a chronic disease that causes abnormal growth of connective tissue. It can affect the joints, skin, and internal organs. It is degenerative and gets worse over time. The disease can be in one area of the body. This is known as localized scleroderma. Or it may affect the whole body. This is known as systemic. Scleroderma Cedars-Sinai. Scleroderma Management and Treatment Cleveland Clinic. Systemic Scleroderma Skin Involvement Hyperpigmentation.. Plaquenil Fatigue, joint pain Mild mostly GI symptoms, except for serious eye problems with chronic use at high dosages Antimalarial drug, frequently used to treat lupus and rheumatoid arthritis. Limited research on specific effectiveness in scleroderma. Imatinib mesylate Gleevec Skin fibrosis, pulmonary Moderate Anti-cancer drug. Localized scleroderma is a rare autoimmune disease with primary affection of the skin, and occasional involvement of the fat tissue, muscle, fascia, and bone. Depending on the clinical subtype, the spectrum of skin lesions ranges from singular plaque lesions to severe generalized or linear subtypes. which may lead to movement restrictions and. Localized scleroderma also known as morphea or linear scleroderma Two/thirds of those diagnosed with scleroderma have the localized form, which affects the skin and not the internal organs as detailed above. Localized scleroderma does NOT evolve into systemic scleroderma.