But there also has to be something negative going on if it's making my hair fall out! mshistory - I know what you're saying is ALL true. I won't let things go to long like this, but I am hoping this is just some sort of rebound effect and that things will level off. I need to find a new one, but with 2 small kids and work full time, who has the time?! like i said i have super thick hair so i still have have a good amount but its def not super super thick like it once was. for those of you losing hair loss-lets be like Dolly Parton and all these other stars and wear wigs! It was making me feel better in other ways -no doubt. As for the psychologist, I did try that over the summer, but was not impressed by the one I was going to. If you remember, most wait at least 3 months before they even see any improvement. i lost a bunch of hair the 1st 4 months and now it has steadied off... along with the extreme dry patchy skin that bleads and all my lovely knew wrinkles along my eyes from doing warm compresses , massage and drops!!! this disease sure takes a toll52 yr old Sj S, APS w/strokes, Autonomic Neuropathy, PN, Nephrogenic DI, (CVID) Ig G def., Cushing's, Asthma, Gastroparesis. Hydroxychloroquine bluelight Chloroquine and osmotic lysis Plaquenil cause dizziness after 2 years Commonly used on holidays in malaria prone destinations, chloroquine and hydroxychloroquine will not be over familiar to the emergency physician. However, it is one of the leading causes of drug overdose in malaria prone countries and also the occasional toddler has managed to consume the grandparents lupus or rheumatoid arthritis medication leading to lethal consequences. Hydroxychloroquine in whole blood. For further detailed information on long half-life drugs, please consult the Individual Product Bioequivalence Recommendation Guidance for Amiodarone HCl Tablets. Bioequivalence based on 90% CI Hydroxychloroquine. Waiver request of in-vivo testing Hydroxychloroquine is taken orally, and rapidly absorbed and metabolized by the liver. It is highly tissue bound and concentrates in melanin-rich pigments like the retina. It is excreted unchanged in the urine, and has a half-life of 45 days. Mechanism Hydroxychloroquine is thought to improve symptoms of systemic diseases by preventing. I thought methotrexate was stronger and had harder side effects??? Being 32 and feeling like I'm way too young to be dealing with any of this but trying to find my way through it BTW, seeing a psychiatrist and dealing with my depression and anxiety seriously saved my life. And your hair is growing back even while you're still on 200 a day? I wonder if what you're noticing is really the change in dose. You need to decided what is more important..or health.52 yr old Sj S, APS w/strokes, Autonomic Neuropathy, PN, Nephrogenic DI, (CVID) Ig G def., Cushing's, Asthma, Gastroparesis. Meds: IVIG & pre-meds, Arixtra, Aspirin, Plaquenil, Cardizem, Toprol XL, Domperidone, Nexium, Midodrine, Symbicort, Fentanyl, Percocet, Zofranthats the hard part---you never know.. If you feel really overwhelmed by all of this, it might be something to consider. now i still have quite a bit of hair but plaquenil made me lose a lot.. I'm wondering if 400 a day is just too much for some of us to handle? I say this because Plaquenil has a chemical half-life of 30-60 days (you can confirm this on wiki or RX info on the drug)--so it takes a LONG time to get out of your system..long for you to notice changes in days. whenever i take something new i think i get a weird side effect--but then again could it just be part of a flare...ughhhhh.. Hydroxychloroquine long half life Let me tell you what weaning down from Plaquenil is like., Contains Nonbinding Recommendations Plaquenil children Both chloroquine and hydroxychloroquine have excellent oral absorption and bioavailability. Both have a long and variable plasma elimination half-life because of a high volume of distribution, an extended mean residence time HCQ 1300 hours and CQ 900 hours and with about half the drug metabolites undergoing unmodified renal clearance. Chloroquine And Hydroxychloroquine Toxicity - StatPearls.. Hydroxychloroquine - American Osteopathic College of.. PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION. Given the long half-life of hydroxychloroquine and the previously documented within day variations of less than 8% this was considered appropriate. All patients in the cohort were prescribed hydroxychloroquine not to exceed a dose of 6.5 mg per kilogram. The maximum daily dose prescribed is 400 mg. Typical daily doses of 200 to 600 mg are used for lupus and rheumatoid diseases. Hydroxychloroquine has a long terminal elimination half-life in blood 40 days, which exceed those in plasma. The oral bioavailability averages 79%. Hydroxychloroquine accumulates in several organs, especially melanin-containing retina and skin. Children should not take hydroxychloroquine for long-term therapy. Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your response to hydroxychloroquine. If you are taking hydroxychloroquine for a long period of time, your doctor will recommend frequent eye exams.