Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Hydroxychloroquine and bloody stools Are hydroxychloroquine and meloxicam the same thing Plaquenil for vasculities rash Hydroxychloroquine Plaquenil; HCQ has been an important and effective drug for the treatment of lupus erythematosus and related autoimmune and inflammatory diseases for half a century, although its potential to cause retinal damage continues to raise concern among rheumatologists and ophthalmologists. If a patient is on a dose that exceeds 5 mg/kg/day of real body weight, the prescribing physician should be contacted to ensure that the dose can be adjusted and medical risks are managed. Jan 03, 2020 Initial adult dosage 400 mg to 600 mg 310 to 465 mg base daily, administered as a single daily dose or in two divided doses. In a small percentage of patients, side effects may require temporary reduction of the initial dosage. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Plaquenil dosage maculopathy Plaquenil hydroxychloroquine sulfate dose, indications., Hydroxychloroquine Plaquenil Dosing Calculator - MDCalc Buy aralen lupusHydroxychloroquine and glaucomaChloroquine poisoning treatmentPlaquenil pyrodermaSide effects stopping plaquenil The risk of plaquenil-induced toxic maculopathy is associated with a cumulative dose level of 1,000 grams and it usually takes 5-7 years for patients on the standard dose of 250-400 milligrams per day to reach that level. 2 Based on a dose of 200 milligrams per day for the past twenty years. Plaquenil-Induced Toxic Maculopathy - Decision-Maker PLUS. Plaquenil Dosage Guide -. The Risk of Retinal Toxicity with Plaquenil. Initially, its manufacturers recommended that hydroxychloroquine dosage be no higher than 6.5 mg/kg of ideal body weight to prevent retinopathy. 1,29,30 However, it has recently been demonstrated that real body weight is a better predictor of risk of retinopathy than ideal body weight when dosing hydroxychloroquine, perhaps because of the increasing variance of real body weight in our patient population. 26 Any daily dose of greater than 400 mg and being prescribed a maintenance dose of more than 6.5 mg/kg/day may increase the likelihood 1. Duration of treatment Taking Plaquenil for more than 5 years and if the total amount taken by the patient reaches more than 1000 g may put the patient at risk for the toxicity 1. The current maximum daily HCQ dose recommended by the AAO is 5 mg/kg of real weight. The 2011 guidelines suggested a maximum dose of 6.5 mg/kg of ideal weight. The biggest difference between the.