It's the first drug most doctors prescribe after you’re diagnosed. It will help ease symptoms like joint pain, fatigue, redness, and swelling. Wiki hydroxychloroquine Low body fat and increase risk for chloroquine toxicity OBJECTIVE To examine the bioavailability of methotrexate MTX in the presence of hydroxychloroquine HCQ, and vice versa, to determine a possible pharmacokinetic explanation for the observation that combination treatment of rheumatoid arthritis with MTX and HCQ has been shown, clinically, to be more potent than MTX used alone. According to the American College of Rheumatology, hydroxychloroquine Plaquenil, is a “disease-modifying anti-rheumatic drug DMARD,” meaning that it helps reduce the pain and swelling that come with arthritis. It can also reduce the incidence of joint damage. Certain drugs do not mix well with methotrexate, so you should tell your doctor about any other medications or supplements you are taking. 4 Doctors often recommend that patients taking methotrexate also take folic acid supplements on a different day to reduce the medication’s side effects. 3 Methotrexate interrupts the process that causes RA inflammation, which damages your joints and organs over time. It may also help prevent damage to your organs and joints. Does hydroxychloroquine always help when taking methotrexate Hydroxychloroquine Plaquenil -, RA and Hydroxychloroquine How Effective is it for. How does plaquenil work on the immune systemChloroquine brane nameHydroxychloroquine photosensitivity rash My rheumatologist put me on prednisolone reduced doses over in 3 months until the methotrexate starts working once a week of 15mg for 2 weeks, 20mg once a week indefinitely. Plaquenil 300mg daily. I also take Vit D daily and 5mg folic acid once a week plus curcumin and fish oil I have been taking it all with breakfast for the last 8 days. Plaquenil User Reviews for Rheumatoid Arthritis at. RA And Methotrexate. RA and Hydroxychloroquine How Effective is it for Rheumatoid.. Methotrexate was out of the question because of my kidney condition. Have been through the Humira, Enbrel and was on Xeljanz until prostate cancer was found. Have been on just the Hydroxychloroquine for about 5 months and the RA is no worse than it ever was. The entire time I've had stomach issues, vomiting. Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. If you have lupus, it may also improve the rash. It may be as long as 12 weeks before you notice the benefits. Hydroxychloroquine is often taken in combination with other drugs such as methotrexate. Plaquenil Hydroxychloroquine is used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus & others.