I do have anxiety disorder but have not had a panic attack in two years and certainly not waves of panic. I have since lost my appetite and can only eat a little. Chloroquine primaquine Chloroquine skin pigmentation Anxiety, Plaquenil, and Lupus. Posted 6/7/2015 PM GMT -6 I have suffered from severe anxiety and depression all my life. With the help of a very good psychologist and psychiatrist, I got the anxiety uner control. 6 months ago I was told I had Lupus. No big deal. Its not like Alzheimers, Parkinsons, or Huntingtons where each day will. I really don’t think the Plaquenil causes anxiety. I think that there are other factors that we deal with related to our illnesses that create anxiety. For example, we over think the illness and ruminate the situation we are in. This leads to other areas of our life suffering. Consumer information about the medication HYDROXYCHLOROQUINE - ORAL Plaquenil, includes side effects, drug interactions, recommended dosages, and storage information. Read more about the prescription drug HYDROXYCHLOROQUINE - ORAL. This didn't make me happy because I really feel that looking for more medication from someone else for sudden symptoms is not a wise choice. It helped me sleep but makes me way too tired during the day -- so it is like I am anxious, panicky, and exhausted now. She said right away that she does not think it is the plaquenil and then suggested I see a psychiatrist. Plaquenil anxiety depression Will you have Stress and anxiety with Plaquenil - eHealthMe, Anxiety and Plaquenil Has anyone experienced mood. - LUPUS UK Forum plaquenilIs uti a side effect of hydroxychloroquine I have had chronic, clinical depression my entire life which I am on meds for. The Plaquenil GREATLY effected by depression. I am no longer taking it. If you Google 'Plaquenil Depression' you will see that it has this effects on others. That's how I got to this post! Hopefully there is something else I can try to deal with my symptoms. Can Plaquenil cause Major Depression? - Treato. HYDROXYCHLOROQUINE - ORAL Plaquenil side effects.. Plaquenil Side Effects Common, Severe, Long Term -. Hi Deb, Yes, Plaquenil causes me serious anxiety. So I have tried different dosage with no success. Honestly, the doctors don't get it, but that doesn't matter to me. Plaquenil and anxiety/depression? - Autoimmune diseases. and my joints were sore so I went back up to my original dose of 400mg but immediately experienced severe and sudden anxiety and depression. I am also on 150mg of zoloft for GAD, OCD and depression which I have largely had under control for the past ten years with occasional little. Plaquenil and Depression - from FDA reports Summary Depression is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take medication Enbrel, and have Pain.