Additionally, another exception occurred while executing the custom error page for the first exception. Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Smoking and plaquenil Ophthalmology guidelines for plaquenil Chloroquine from quinine Plaquenil toxicity is poorly understood. It is believed the medication molecules bind to the pigment melanin at the base of the retinal retinal pigment epithelium causing metabolic changes and toxic effects. Chloroquine and hydroxychloroquine belong to the quinolone family. Although their therapeutic and toxic doses differ, they are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity. Initially, chloroquine was given for malaria prophylaxis and treatment. Although it is considered rare, retinal toxicity from the intake of Plaquenil can be irreversible even if the drug is discontinued 2, 3. What is Plaquenil Toxicity? The toxicity resulting from the intake of Plaquenil is due to its affinity for melanin-containing structures in the body. Malaria is common in areas such as Africa, South America, and Southern Asia. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Is plaquenil toxic Plaquenil Side Effects Common, Severe, Long Term -, Chloroquine and Hydroxychloroquine Toxicity Practice. Oct findings in plaquenil toxicityCan hydroxychloroquine cause dry eyes Once retinal toxicity from hydroxychloroquine occurs, it is thought that the retinal changes are permanent and the disease can progress even if hydroxychloroquine is stopped for 1 to 3 years. Newer techniques for evaluation of retinal disease have been developed and these techniques can detect retinal toxicity earlier. My Take on New Ocular Screening Guidelines for Plaquenil.. Plaquenil Toxicity - Symptoms, Treatment, Risk Factors, Retinopathy. The Risk of Retinal Toxicity with Plaquenil. Although they are uncommon, Plaquenil has side effects that may affect your eyes. Plaquenil and Your Eyes In some people, Plaquenil can cause a condition called hydroxychloroquine retinopathy, often referred to as bulls-eye maculopathy. Plaquenil is in a class of medicines known as antimalarials. It's a less toxic version of the older antimalarials, including quinine and chloroquine. Plaquenil received an overall rating of 5 out of 10 stars from 4 reviews. See what others have said about Plaquenil, including the effectiveness, ease of use and side effects. Plaquenil Reviews.