Estrogen use should be discontinued unless its need outweighs its adverse effects on porphyrin metabolism. After achievement of remission, estrogen therapies may be cautiously reinstituted; however, the duration of remissions may be shortened. Does plaquenil cause dizziness the longer you take it Sam's club pharmacy hydrochloride hydroxychloroquine Hydroxychloroquine oral tablet is used for short-term treatment of malaria, but it may be used for long-term treatment of lupus or rheumatoid arthritis. Hydroxychloroquine comes with risks if you. Porphyria cutanea tarda, the most common type of porphyria worldwide, is caused by a deficiency of uroporphyrinogen decarboxylase, a crucial enzyme in heme biosynthesis, which results in an accumulation of photosensitive byproducts, such as uroporphyrinogen, which leads to the fragility and blistering of sun-exposed skin. Read "Low-Dose Hydroxychloroquine Is as Effective as Phlebotomy in Treatment of Patients With Porphyria Cutanea Tarda, Clinical Gastroenterology and Hepatology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. If symptoms recur, re-treatment can restore remissions. Remissions may last from several months to many years. Low-dose hydroxychloroquine role in porphyria Hydroxychloroquine DermNet NZ, Porphyria cutanea tarda a case report Journal of Medical Case. Will plaquenil cause weight gainPlaquenil and diarrhea does it stopPlaquenil bijwerkingenPlaquenil increases sed rateGoodrx plaquenil BACKGROUND & AIMS Porphyria cutanea tarda PCT is an iron-related disorder caused by reduced activity of hepatic uroporphyrinogen decarboxylase; it can be treated by phlebotomy or low doses of hydroxychloroquine. Low-dose hydroxychloroquine is as effective as phlebotomy.. Low-Dose Hydroxychloroquine Is as Effective as Phlebotomy in. - DeepDyve. Low-Dose Hydroxychloroquine Is as Effective as Phlebotomy in Treatment.. Porphyria Cutanea Tarda and Polymorphous Light Eruptions. Has been used in treatment of porphyria cutanea tarda†. 114 116 117 See Patients with Psoriasis or Porphyria under Cautions. Has been effective in some cases when used in the treatment of polymorphous light eruptions†. Hydroxychloroquine Sulfate Dosage and Administration Administration Iron chelators are less effective than phlebotomy or low dose hydroxychloroquine or chloroquine in treating individuals with PCT. However, these drugs may play a role in treating affected individuals in whom the use of the two front-line therapies is not possible, such as individuals with end stage renal disease who are on hemodialysis. CONCLUSIONS Hydroxychloroquine, 100 mg twice weekly, is as effective and safe as phlebotomy in patients with PCT, although noninferiority was not established. Given these results, higher-dose regimens of hydroxychloroquine, which have more side effects, do not seem justified.