Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Novo-chloroquine 250 mg side effects Eye test for plaquenil toxicity Skin discoloration - bluish is found among people who take Plaquenil, especially for people who are female, 40-49 old, have been taking the drug for 2 - 5 years, also take medication Imuran, and have Epilepsy A total of 41 patients 38 women and 3 men were included in the study. The mean age was 39.2 ± 15.4 years. The hydroxychloroquine was indicated for systemic lupus erythematosus in 73.2%, dermatomyositis in 12.2%, rheumatoid arthritis in 9.8%, actinic lichen and sarcoidosis each in 2.4%. Druginformer Identified Side Effects Arthralgia, Chest pain, Pruritus, Skin hyperpigmentation, Oral disorder, Lupus-like syndrome. Posted By Anonymous in on July 11, 2006 @ am “. Plaquenil worked well on my symptoms, but it started to make me itchy and caused skin pigmentation. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil hyperpigmentation Subacute Cutaneous Lupus Erythematosus SCLE - Dermatology., Hydroxychloroquine-induced hyperpigmentation in systemic. Plaquenil and oral pigmentationHydroxychloroquine drug classificationChloroquine ciprofloxacinChloroquine for fish ich Hydroxychloroquine-induced pigmentation lesions usually begin after a few months or years of treatment. When we compared our patients with the controls, we found no significant association with the duration of HCQ treatment or with the cumulative dose of HCQ. Hydroxychloroquine-Induced Pigmentation in Patients With Systemic Lupus.. Mycophenolate Mofetil Skin Hyperpigmentation Reports.. Hydroxychloroquine-induced Hyperpigmentation of the Skin.. Some medications, such as plaquenil and minocycline, can cause permanent dark skin plaques, which resemble black and blue marks similar to morphea scleroderma. Cosmetically, pigmentation differences can be covered up with corrective cosmetics, such as Dermablend. Drug-Induced Hyperpigmentation caused by Minocycline Minocin Antibiotic Hydroxychloroquine is an antimalarial medication that can cause hyperpigmentation of nails, mucosa, and skin 1–5. Retrospective studies cite the incidence of drug-related hyperpigmentation from hydroxychloroquine to be as high as 33% of individuals. Elder abuse is a cause of significant morbidity and mortality in older individuals 7–9. Dark patches on your skin can also emanate from clumps of excess melanin, the skin’s brown pigment, as explained by American Osteopathic College of Dermatology. The condition is called hyperpigmentation and might result from several causes. True hyperpigmentation is not an indication of a serious medical condition.