Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. At risk lifetime dosage of hydroxychloroquine Plaquenil use during pregnancy Corneal deposits called vortex keratopathy or corneal verticillata result from binding to cellular lipids and deposition of the drug in the basal epithelial layer of the cornea. Discontinuation of the drug usually causes the deposits to disappear over time. Cornea verticillata, also called vortex keratopathy or whorl keratopathy, is a condition characterised by corneal deposits at the level of the basal epithelium forming a faint golden-brown whorl pattern. It is seen in Fabry disease or in case of prolonged amiodarone intake. Causes Amiodarone Fabry’s disease Chloroquine Hydroxychloroquine Indomethacin Phenothiazines etc. Corneal verticillata, also called vortex keratopathy, are one type of corneal deposits. Verticillata are readily recognizable by their distinct appearance as fine, golden-brown or gray opacities that are almost always bilateral. The opacities branch out from a central whorl, usually across the inferior cornea. The most common causes of verticillata include Amiodarone Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Plaquenil corneal verticillata Early Plaquenil Toxicity Detected without Bull’s Eye., Cornea verticillata - Wikipedia Plaquenil and mosquito bitesPlaquenil side effects during pregnancy Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina. Chloroquine can also induce cataract formation; however, no reports of hydroxychloroquine and cataract have been reported. This article focuses upon hydroxychloroquine retinopathy. Disease Hydroxychloroquine toxicity - EyeWiki. Corneal verticillata - Amiodarone. Chloroquine Toxicity, Cornea Verticillata SpringerLink. If you are taking Plaquenil to treat an inflammatory condition or malaria, you should be aware of the side effects that may occur to your eyes and vision. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Plaquenil side effects start off by effecting the surface of the eye the cornea leading to verticillata. Verticillata are deposits of salts within the corneal epithelium. This does not cause any symptoms to the patient and is reversible when the medication is stopped.