Excessive production of melanin is responsible for this condition. Hyperpigmentation can occur on almost any part of the body, including the face, neck, hands, arms and legs. Does plaquenil cause melanoma Chloroquine description Its high citric acid content makes it a natural bleaching agent. You can squeeze fresh lemon, dip a cotton ball in it, apply directly on the dark spots, leave it on for 15–20 minutes, and wash it off with cold water. To try your own version of this hyperpigmentation treatment at home Add a tablespoon of fresh black tea leaves to a cup of boiling distilled water. Steep for two hours and strain to remove the leaves. Soak a cotton ball in the tea water and apply to areas of hyperpigmentation, twice a day. HYPER PIGMENTATION TREATMENT. There are a wide range of treatments your dermatologist can offer you. Depending on the proper reason and severity, there may be different treatment options. Microdermabrasion is a light cosmetic procedure to treat the hyperpigmentation. External factors like excessive sun exposure, skin injury, burning, emotional stress or contact with certain chemicals can also cause hyperpigmentation. The root cause of excess melanin production is generally attributed to internal factors like hormonal changes in the body, pregnancy and various health problems. Natural treatments plaquenil hyperpigmentation Top 13 Home Remedies for Pigmentation on Face, Home Remedies for Pigmentation How to Remove Dark Spots Chloroquine concentration lysosomeHow long is plaquenil in your systemWhat type pof drug is plaquenilSide effects of hydroxychloroquine tablets 200 mg Horseradish is widely used for natural skin care because of its capacity to reduce all types of skin discolorations, blemishes, and scars, and it is one of the most effective melasma home remedies also. This remedy works by bleaching the skin and lightening undesired discoloration and hyper pigmentation of the skin. Natural Home Remedies to Treat for Melasma Pigmentation. Home Remedies for Hyperpigmentation Get Rid of.. Home Remedies To Get Rid Of Hyperpigmentation Naturally. Answer. Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong. Check out the wonderfully effective natural home remedies for hyperpigmentation and step out of your home like the queen of beauty and radiance. And what’s more, you don’t have to go to a salon and spend a fortune on the ugly dark patches but can do it right at your home for the best results. The statistical associations of HCQ-induced pigmentation with several variables were calculated using univariate and multivariate analyses. RESULTS Among the 24 patients, skin pigmentation appeared after a median HCQ treatment duration of 6.1 years range, 3 months-22 years.