While there is good clinical evidence demonstrating the drug’s efficacy in rheumatoid arthritis and lupus, there are very few studies looking at hydroxychloroquine as a treatment for Sjögren’s. The studies that do exist show mixed results (some show Nonetheless, despite the lack of clinical studies, rheumatologists feel that hydroxychloroquine may have a potential beneficial effect in helping patients with symptoms of fatigue and achiness, which are common complaints in patients with Sjögren’s. Map of chloroquine resistant malaria Chloroquine pregnancy risk Started Plaquenil 15 days ago and noticed immediate improved in fatigue. By 12-th day the fatigue was gone just to return back 3 days ago. Is this common? How did the Plaquenil work for you? I knew it takes time to work but I was not expected such a fast improvements and then return of the fatigue? Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Talk to your doctor about other drug options that may work for you. How to Lose Weight Fast 3. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. This medicine is not effective against all strains of malaria. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. The good news is that hydroxychloroquine targets the immune system without causing an increase in the risk of infection or cancer that can be seen with other immunosuppressant medications. How the drug works is unclear, but recent research has pointed to an inhibitory effect on toll-like receptors that are proteins involved with inflammation. How fast does plaquenil work Hydroxychloroquine Side-effects, uses, time to work, Hydroxychloroquine Side Effects, Dosage, Uses, and More Macular thinning plaquenilPlaquenil maximum dosageRates of plaquenil toxicitySide effects of plaquenil 400 mg Hydroxychloroquine is a DMARD. The brand name is Plaquenil. What does Plaquenil do? Plaquenil relieves pain and swelling and prevents damage to joints. How long does Plaquenil take to work? Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. Plaquenil Overview, How to Take, Side Effects, Precautions.. Hydroxychloroquine Plaquenil. Flesh colored itchy rash on top of feet and inside ankle. I do take plaquenil hydroxychloroquine 400mg daily fo more Flesh colored itchy rash on top of feet and inside ankle. I do take plaquenil hydroxychloroquine 400mg daily for ra. Havent changed soaps, detergents, etc. May 07, 2019 plaquenil hydroxychloroquine is commonly used to help keep mild lupus-related problems, such as skin and joint disease, under control. this drug is also effective at preventing lupus flares. My question is for those that have taken Plaquenil/Hydroxychloroquine. How long did it take for it to remove symptoms in your personal experience? I know I've read it can take up to 6 months but what I'm wondering is, do you just wake up one day and find it's kicked in 6 months down the road or more likely, it starts to work slowly over 6 months?