Dissolve about 6 mg in 2 m L of sulfuric acid, and allow to stand for 5 minutes: an orange color is produced. Pour the solution into 10 m L of water: the color changes first to yellow and then, gradually, to bluish green. Prepare a suitable filtered mixture of water, peroxide-free tetrahydrofuran, and methanol (6) such that at a flow rate of 1.0 m L per minute, the retention times of prednisone and acetanilide are about 8 and 6 minutes, respectively. the relative standard deviation is not more than 2.0%; and the resolution factor between prednisone and the internal standard is not less than 3. Prednisone is used for many different autoimmune diseases and inflammatory conditions, including: asthma, COPD, CIDP, rheumatic disorders, allergic disorders, ulcerative colitis and Crohn's disease, adrenocortical insufficiency, hypercalcemia due to cancer, thyroiditis, laryngitis, severe tuberculosis, urticaria (hives), lipid pneumonitis, pericarditis, multiple sclerosis, nephrotic syndrome, sarcoidosis, to relieve the effects of shingles, lupus, myasthenia gravis, poison oak exposure, Ménière's disease, autoimmune hepatitis, giant-cell arteritis, the Herxheimer reaction that is common during the treatment of syphilis, Duchenne muscular dystrophy, uveitis, and as part of a drug regimen to prevent rejection after organ transplant. It is important in the treatment of acute lymphoblastic leukemia, non-Hodgkin lymphomas, Hodgkin's lymphoma, multiple myeloma, and other hormone-sensitive tumors, in combination with other anticancer drugs. Prednisone can be used in the treatment of decompensated heart failure to increase renal responsiveness to diuretics, especially in heart failure patients with refractory diuretic resistance with large dose of loop diuretics. In terms of the mechanism of action for this purpose: prednisone, a glucocorticoid, can improve renal responsiveness to atrial natriuretic peptide by increasing the density of natriuretic peptide receptor type A in the renal inner medullary collecting duct, inducing a potent diuresis. Short-term side effects, as with all glucocorticoids, include high blood glucose levels (especially in patients with diabetes mellitus or on other medications that increase blood glucose, such as tacrolimus) and mineralocorticoid effects such as fluid retention. The mineralocorticoid effects of prednisone are minor, which is why it is not used in the management of adrenal insufficiency, unless a more potent mineralocorticoid is administered concomitantly. It can also cause depression or depressive symptoms and anxiety in some individuals.
BCS; permeability; prednisone; regulatory science; solubility. INTRODUCTION. A monograph based on literature data is presented on prednisone with respect. Nov 7, 2013. Prednisone is about 5 times more potent on a weight basis than cortisone in. Prednisone is used in the management of conditions generally.