Kramer Amoxicillin is an improved version of the antibiotic penicillin; touted for having a broader range of activity and being more resistant to stomach acids than naturally-occurring penicillin. The drug kills bacteria by disrupting the formation of their cell walls and is often prescribed by veterinarians to combat bacterial infections in pets. “In my experience, amoxicillin is a safe antibiotic when appropriately prescribed by a veterinarian and used by the pet owner,” says Dr. “Amoxicillin treats many common bacterial infections, including some of those affecting the mouth, respiratory tract, skin, urinary and digestive tracts, and others.” “The most common side effect” of amoxicillin, Mahaney says, “is upset.” According to Mahaney, amoxicillin is not recommended for dogs that have previously exhibited clinical signs of intolerance or an allergic reaction. He says that intolerance can include signs such as digestive upset (vomiting, diarrhea, or lack of appetite), , seizures and coma. Adam Denish of Rhawnhurst Animal Hospital in Elkins Park, PA. “I wouldn’t single out amoxicillin in general for negative interactions,” Denish says, “most [side effects] are just minor. However, it would be prudent to tell your veterinarian if any side effects occur. In some cases, we discontinue the drug or adjust the dose. Β-lactamase−producing strains of Haemophilus influenzae and Moraxella catarrhalis Mild to moderate: 500/125 mg PO q12hr or 250/125 mg PO q8hr for 10 days Severe: 875/125 mg PO q12hr or 500/125 mg PO q8hr or 2000 mg (2 extended-release tabs) PO q12hr for 7-10 days Take with meals to avoid GI upset Take suspension at start of meal to enhance absorption Dysphagia: May substitute 250 mg/5 m L suspension for 500/125 mg tablet; may substitute 200 mg/5 m L or 400 mg/5 m L suspension for 875/125 mg tablet Because of the different amoxicillin-to-clavulanate ratios in the 250-mg tablet (amoxicillin 250 mg, clavulanate125 mg) and the 250-mg chewable tablet (amoxicillin 250 mg, clavulanate 62.5 mg), the 250-mg tablet should not be used if the pediatric patient weighs Hypersensitivity reactions Anaphylaxis Anemia Thrombocytopenia Leukopenia Agranulocytosis Hepatoxicity AST/ALT elevation Pseudomembranous colitis Serum sickness Abdominal discomfort Cholestatic jaundice Flatulence Allergy to cephalosporins, carbapenems Different tablets are not interchangeable, because ratios of amoxicillin to clavulanate are different Extended release tablets not for use in renal impairment (Cr Cl Amoxicillin binds to penicillin-binding proteins, thus inhibiting final transpeptidation step of peptidoglycan synthesis in bacterial cell walls; addition of clavulanate inhibits beta-lactamase-producing bacteria, allowing amoxicillin extended spectrum of action It is a semisynthetic antibiotic with a broad spectrum of bactericidal activity, covering both gram-negative and gram-positive microorganisms Not effective against Mycoplasma and Legionella spp Peak plasma time: 2 hr (amoxicillin); 1.1 hr (clavulanic acid) Peak concentration: 8-22 mcg/m L (amoxicillin); 0.8-2.6 mcg/m L (clavulanic acid) AUC: 40-80 mcg•hr/m L (amoxicillin); 2-6 mcg•hr/m L (clavulanic acid) The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.
Dec 11, 2018. Amoxicillin is used to treat infections caused by bacteria, such as ear infections, bladder infections etc. Includes amoxicillin side effects. Each tablet contains 875 mg amoxicillin as the trihydrate. performed in mice and rats at doses up to 2000 mg/kg 3 and 6 times the 3 g human dose, based on.