C57BL/6 male mice were fed for 10 weeks with standard chow or high-fat diet. Lean and obese mice were treated with the insulin sensitizer metformin (300 mg/kg/day, 2 weeks). Intracavernosal pressure (ICP) and in vitro corpus cavernosum (CC) relaxations to both acetylcholine and electrical field stimulation, as well as phenylephrine-induced contractions, were obtained. Levels of cyclic guanosine monophosphate in CC were detected by enzyme immunoassay. High-fat-fed mice exhibited higher body weight and insulin resistance. Cavernous nerve stimulation caused frequency-dependent ICP increases, which were significantly lower in obese compared with lean mice (Treatment with metformin restored the erectile function in obese mice, through improvement of in vitro endothelial and nitrergic cavernosal relaxations. Therefore, use of metformin may be a good pharmacologic approach to treat insulin resistance–associated erectile dysfunction. You've seen the ads on television, you've heard the jokes, and, if you're like most men, you've tried your best to block it from your mind. But if you have diabetes, this is one touchy subject you shouldn't ignore. A full 75 percent of diabetic men have some trouble achieving or maintaining an erection long enough to have intercourse. But diabetes doesn't have to be a deathblow to your sex life. You can protect your sexual functioning by keeping your diabetes under control. And if the condition has already started to derail your physical relationships, your doctor can help you get back on track. Erections take teamwork from several parts of the body: Your brain makes you aroused, your nerves sense pleasurable feelings, and your arteries carry a flood of blood to the penis. Unfortunately, poorly controlled diabetes can ruin that teamwork.
Insulin-resistant men had significant improvement in erectile function when metformin was added to sildenafil(Viagra), according to data from a small clinical study. Knoblovits noted that, erectile function depends in large part on the release of nitric oxide by the vascular endothelium. D., of Hospital Italiano de Buenos Aires in Argentina, reported at the Endocrine Society meeting that, sildenafil alone had failed to improve erectile function, and men who received a placebo in addition to the phosphodiesterase-5 (PDE5) inhibitor continued to have erectile problems, “We think metformin potentiates the activity of sildenafil by improving insulin resistance and nitric oxide activity in the vascular endothelium of the penis.” Dr. Sildenafil and other PDE5 inhibitors improve erectile function by inhibiting the breakdown to nitric oxide. Obesity, metabolic syndrome, and Type 2 diabetes all interfere with nitric oxide-mediated endothelial function. The three conditions are characterized by insulin resistance, which can interfere with PDE5 inhibitors’ ability to prolong the effects of nitric oxide on penile vascular endothelium, Dr. To determine whether the drug has similar activity in humans, investigators studied 30 insulin-resistant men who had significant erectile dysfunction despite treatment with sildenafil. Knoblovits reported that 17 men used sildenafil on demand plus metformin 1,700 mg/day, and the remaining 13 used sildenafil and placebo. Evaluations at baseline and after two and four months of treatment included calculation of body mass index and waist circumference; measurement of insulin and glucose; calculation of insulin resistance by homeostatic model assessment (HOMA); evaluation of adverse events; and evaluation of erectile function by means of the International Index of Erectile Function 5 (IIEF-5). Baseline IIEF-5 score averaged 14.3 in the metformin group and 15.2 in the placebo group. Diabetes can affect sexual function, and as uncomfortable as it may sound, you may need to discuss this with your doctor (and certainly with your partner). To help you out, I have done research to bring you information about this most sensitive of subjects. First of all, having any chronic disease may in itself cause anxiety, which can result in sexual dysfunction. But having said that, it is also true that diabetics do report more sexual dysfunction than the populations at large. In his book Talking About Sex (American Psychiatric Press, Inc., 1995), Derek C. Polonsky, MD states that 20% of people with diabetes, both men and women, report sexual dysfunction. Please read the following with an open mind, not looking for something bad which will happen to you or a loved one.
Can Metformin Cause Erectile Dysfunction OnlinePharmacyworldwidestore best ED products - Generic Levitra, Tadalafil Cialis, Vardenafil levitra with lowest price. Erectile dysfunction — the inability to get or maintain an erection firm enough for sex — is common in men who have diabetes, especially those with.