For those who have more than 2 severe headaches/month and in patients with complicated migraine (migraine with stroke-like features), a daily medication may be worth while. These are generally highly effective (about 75% effective), but do require daily regular use. Some in mysterious ways, possibly through manipulations of serotonin(e.g. More information about these is in the next section. Migraine is a "committee disease", with multiple genetic variants (probably thousands). Only about 3-5% of migraine patients use prevention medications, according to Gray (1999). Mechanistically, these drugs seem to work via several pathways: some are beta-blockers (e.g. It seems extremely likely that there is no single drug that will "work" in this collection of at least 12 genes, found to various extents in persons with migraine, that share some common features. These drugs fall into 5 major classes: anticonvulsants, antidepressants, antihypertensives, dopamine blockers, and Botox (? Inderal, Corguard), some are calcium channel blockers (e.g. In other words, prevention of migraine is a "trial and error" process. If one accepts the idea that there are thousands of variants of Migraine (associated with various combination of genetic traits), it also follows that "adding on" one medication to another, may not be the best strategy. To use a military analogy, the additive strategy is based on the core assumption that one knows one's target, and one is just concentrating more firepower. If the targets are all over genetic map, one does not know for sure that one's weapons are even pointing in the same direction. Because migraine is basically a disorder where people check off symptoms and then they have "migraine", there is almost certainly very substantial mixture between many different disorders that have the same symptoms. Most people have headaches at some point in their lives. Doctors have identified 200 different types of headaches, and the proper treatment depends on which type you have. Most headaches are relatively harmless, but some can be debilitating or may point to serious or even life-threatening underlying conditions. Fortunately, there are several measures you can take to treat the most common headaches, and certain “red flags” can help you recognize when you need immediate medical attention. Tension headaches, also known as myogenic or muscle contraction headaches, are the result of tensing of the facial and neck muscles. Their underlying causes include stress, anxiety, depression, sleep problems and jaw clenching. Typically, the pain is constant and can be located anywhere throughout the head or neck. Sometimes people describe the pain as feeling like a “hatband” or a “vise,” and it can vary widely in frequency, intensity and duration.
Dec 9, 2015. The economic annual impact of migraines is considerable and has been. Propranolol and metoprolol have the best evidence in migraine. For many people, migraines are debilitating events. beta blockers metoprolol, propranolol, and timolol; the triptan drug, frovatriptan Frova.