Valacyclovir (Valtrex, marketed by Glaxo Smith Kline) and acyclovir (Zovirax, marketed by Sanofi-Aventis) are used mainly for treatment of genital herpes. Both are antiviral drugs and can be taken orally to shorten herpes symptoms or to prevent this infection from recurring in healthy individuals. Acyclovir pills had been in use from 1991 and enjoying the status of a first-of-its-kind antiviral drug for genital herpes treatment, until Valtrex was approved by the US Food and Drug Administration (FDA) 4 years later in 1995. The valacyclovir vs acyclovir debate started since then and it still remains a matter of research interest as to which drug you can use to cope with herpes better. Valacyclovir advantages Valacyclovir has a number of key advantages over other similar antiviral medications. Clinical trials have shown that this drug has greater effectiveness in dealing with the herpes simplex virus (HSV) or the varicella zoster virus (VZV), compared to acyclovir or other drugs. Another plus factor of Valtrex is that it is probably the only medicine that can reduce the risk of herpes transmission, given that safe sex methods are used. However, it is well documented that valtrex and acyclovir perform very similarly. Valtrex is actually converted into acyclovir by the liver, so essentially, the two drugs act the same way in the body to suppress the virus. If acyclovir improves your quality of life, I would stick with it and explain the similarities to your partner - they are well documented and I expect you can find information in scholarly journals that supports the suppressive activity of acyclovir. Valtrex is the dominant brand name, valacylcovir the generic name. (Probably not harmful, but not recommended.) You get maximum effectiveness against oral herpes with the 2 g (2000 mg) dose taken twice a day apart; higher, more frequent, or more prolonged treatment will make no difference. 2) You are typical in not having an identifed trigger of your outbreaks. it is design to suppress outbreak's ..the confusion is the volume of medication..400mg vs 200mg 3x for 7days Valtrex..2x a day for 7-10 day's ..explaining on directions is wrong in fact and why it is used .... I don't know..what it means is (this way of= taking it is design to take when you have a outbreak.if i have a out break... Boom...( I take it this way for 7 to ten day's to suppress the current outbreak).what about the gray area's.
It is design to suppress outbreak's ..the confusion is the volume of medication..400mg vs 200mg 3x for 7days Valtrex..2x a day for 7-10 day's ..explaining on directions is wrong in fact and why it is used .... I don't know..what it means is (this way of= taking it is design to take when you have a outbreak.if i have a out break... Boom...( I take it this way for 7 to ten day's to suppress the current outbreak).what about the gray area's. At first I was getting cold sores about every 4 to 6 weeks. I then started taking 500 mg of Valtrex daily for suppression therapy. This seemed to reduce the frequency of my outbreaks to about once every 2 to 3 months. To save money, my insurance switched me to acyclovir (400 mg twice a day) with similar results as the Valtrex. But like all medications, the herpes antiviral DO have side effects. Here's what you need to know about Zovirax, Valtrex and Famvir. You should know the difference between these different herpes medicines so you can make the best decision for you and minimize any side effects. Here's what you need to know: The major drugs that doctors use to treat the herpes simplex virus (HSV) are antiviral agents called nucleosides and nucleotide analogues. They work by blocking reproduction of the herpes simplex virus. There are other antiviral similar to these drugs that are available in topical and intravenous formulations, but they are generally used to treat different viruses. These drugs are acyclovir, valacyclovir, famciclovir. Acyclovir, Valacyclovir and famcyclovir can lessen the severity of a primary outbreak, reduce the time it takes genital herpes outbreaks to heal and can decrease the number of days of symptoms and days the virus is transmissible. These antiviral medications are most effective when taken early in the course of an outbreak -- when you first feel the tingling and pain.
Human Resources for the University of Oklahoma. Serving Faculty and Staff in Norman, Oklahoma City, and Tulsa campuses. Abstract Purpose To compare the efficacy of 1–year treatment with valacyclovir versus acyclovir in preventing recurrences of herpes simplex virus HSV eye.