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The study - conducted in nonhuman primates with brain structures and functions similar to those of humans - found that the antidepressant sertraline, a selective serotonin reuptake inhibitor (SSRI) marketed as Zoloft, significantly increased the volume of one brain region in depressed subjects but decreased the volume of two brain areas in non-depressed subjects. "These observations are important for human health because Zoloft is widely prescribed for a number of disorders other than depression," said Carol A. D., professor of pathology-comparative medicine at Wake Forest Baptist and lead author of the study, published in the current online issue of the journal Neuropharmacology. In the study, 41 middle-aged female monkeys were fed a diet formulated to replicate that consumed by many Americans for 18 months, during which time depressive behavior in the animals was recorded. Female monkeys were chosen for this study because depression is nearly twice as common in women as men and the use of antidepressants is most common in women ages 40 to 59. After the 18-month pre-study phase, the monkeys were divided into two groups balanced for body weight, body mass index and depressive behavior. For the next 18 months, 21 monkeys received sertraline in daily doses comparable to those taken by humans while a group of 20 received a placebo. This treatment regimen is analogous to a human taking an antidepressant for approximately five years. Hey lefty, It is difficult to say how much venlafaxine (Effexor) is equal to 250mg Zoloft, because it is like comparing apples to oranges, they are both fruit but not the same kind. Anyway, the Zoloft is usually prescribed in the 50 to 200mg range while the Effexor is prescribed in the 75 to 375 mg range. You are on a high dose of Zoloft and in order to change antidepressants would need to taper off one while slowly increasing the other. This can only be done under the supervision of a doctor. If you try to stop the Zoloft without decreasing slowly you run the risk of serious withdrawls. Hope this helps, Laurie Hi lefty16 This question of yours is of great interest to me because like me I had been on Zoloft for a period of 8 years because at that time I was experiancing depression, anxiety also stress,& can say the drug worked OK for about 5 years then stopped helping these issues but I continued taking it because I was worried about coming off it due to side effects ( withdrawal ) so continued taking this drug for a further 3 years. By this time my stress & anexiety levels were so high I felt out of control so went to my doctor who put me onto the new drug on the market called Pristiq.
Home › Forums › Discussion / Questions › Zoloft overdose amount mg. This topic contains 0 replies, has 1 voice, and was last updated by softfedelri1983 7 months, 3 weeks ago. Consumer information about the medication AZITHROMYCIN 250/500 MG - ORAL Zithromax, includes side effects, drug interactions, recommended dosages, and storage information.